The methodologies for health risk assessment are important tools to assist in the management and mitigation of places contaminated by chemicals compounds. In this paper, it is proposed a new methodology for risk assessment by exposure to chemical compounds, called SysRisk, which aims the dynamic exposure assessment and risk characterization in quantitative approaches and qualitative approaches, considering the space-time matrix of the contaminated scenario. The SysRisk was applied in a scenario reported by other authors about the environmental contamination with metals Fe, Zn, Co and Pb in environmental compartments water and soil, caused by the activity of a metallurgical zinc in Duque de Caxias, Rio de Janeiro - Brazil. The results obtained by SysRisk were compared with the results of the reported study. The comparison showed significant differences in the characterization of quantitative and qualitative risk between the two approaches. The SysRisk additionally showed the ability to carry out a detailed spatio-temporal analysis that considers the individual and synergistic effects of multiple contaminants, and offers new subsidies for more efficient mitigation actions differentiated by affected place and time period.
